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when co-administrating vs during co-administration

Both "when co-administrating" and "during co-administration" are correct, but they are used in different contexts. "When co-administrating" is used to refer to the action of administering two or more substances simultaneously, while "during co-administration" is used to describe a period of time when substances are being administered together.

Last updated: March 25, 2024 • 564 views

when co-administrating

This phrase is correct and commonly used in the context of administering multiple substances simultaneously.

This phrase is used to describe the action of administering two or more substances at the same time.

Alternatives:

  • while co-administrating
  • whenever co-administrating
  • as co-administrating

during co-administration

This phrase is correct and commonly used to describe a period of time when substances are being administered together.

This phrase is used to describe the period of time when two or more substances are being administered together.
  • It should be noted that the relationship between sirolimus trough concentration and AUC is changed during co-administration with posaconazole.
  • In addition, oral posaconazole (200 mg or 400 mg) prolonged the mean terminal half-life of midazolam from approximately 3-4 hours to 8- 10 hours during co-administration.
  • Increased aliskiren exposure during co-administration of CYP3A4 inhibitors that also inhibit P-gp can therefore be expected (see P-glycoprotein interactions below).
  • If the dose of nifedipine is increased during co-administration of both medicines, a reduction of the nifedipine dose should be considered when the treatment with phenytoin is discontinued.
  • Phenytoin concentrations should be monitored during co-administration with nelfinavir.
  • As ibuprofen may decrease the clearance of aminoglycosides, strict surveillance of their serum levels is recommended during co-administration with ibuprofen.
  • Caution is advised during co-administration with CYP2B6 substrates (e. g. bupropion, efavirenz, cyclophosphamide).
  • Sirolimus concentrations should be measured upon initiation, during co-administration, and at discontinuation of posaconazole treatment, with sirolimus doses adjusted accordingly.
  • The exposure of CYP2D6 substrates (e. g. tricyclic antidepressants and antipsychotics) may be increased during co-administration of Ranexa, and lower doses of these medicinal products may be required.
  • Thereafter blood levels of ciclosporin should be monitored carefully during co-administration, and upon discontinuation of posaconazole treatment, and the dose of ciclosporin should be adjusted as necessary.
  • Thereafter blood levels of tacrolimus should be monitored carefully during co-administration, and upon discontinuation of posaconazole, and the dose of tacrolimus should be adjusted as necessary.
  • 6 to antiretroviral agents that are substrates of CYP3A4 is recommended during co-administration with posaconazole.
  • However, since decreased clearance of diazepam, with a prolonged half-life have been reported during co-administration of ciprofloxacin and diazepam, and in very rare cases with midazolam, careful monitoring of benzodiazepine therapy is recommended.
  • However, since decreased clearance of diazepam, with a prolonged half-life have been reported during co-administration of ciprofloxacin and diazepam, and in very rare cases with midazolam, careful monitoring of benzodiazepine therapy is recommended.

Alternatives:

  • in the course of co-administration
  • throughout co-administration
  • while co-administration

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