upset vs setback

Some examples from the web:

• This follower named Sagara upset me.
• Our accident got him pretty upset.
• Furthermore many magnesium salts contain sufficient amounts of ammonia to upset biological balances.
• European contact upset the balance and brought negative energy.
• Which means either Ziva really upset someone or...
• You're upset about our marriage conversation.
• And the fact that you don't know why I'm upset makes me doubly upset.
• I know that you were upset, and we all say things we don't mean when we're upset.
• When Santelli showed me the pictures, I was upset.
• Cons are always upset about something.
• Cruchot, your wife was really upset.
• The upset win is sweet vindication for the unranked Commandos.
• French elections have had an upset.
• Mother became very confused, very upset.
• You seemed really upset by the verdict.
• Boyd's here to disrupt and upset.
• Illegal downloading has upset big organizations in Hollywood...
• You were very upset when she passed.
• My brother said you were pretty upset.
• Unfortunately, his aggressive style has upset some long-term clients...

Some examples from the web:

• Now, this most recent setback has been a little disturbing.
• Okay, this is a setback.
• I will handle this setback in my own way.
• Jane, nobody's blaming you for the setback.
• He doesn't let every little setback eat him up inside.
• This whole year has been one setback after another for her.
• A minor setback, that's all.
• Excuse me, Titi, a small setback on the Stock Exchange.
• We just had a little setback.
• Anything else is just a setback.
• Perhaps this setback's a blessing.
• Concordia must move forward despite this setback.
• He had a minor setback yesterday, Marshall.
• I'm not giving up because of one setback.
• This is just a temporary setback.
• I take it we had a setback.
• It's a minor setback for you.
• That was just a minor setback.
• Think we need to put today's little setback behind us.
• Mr. Lazarus has had a setback, he had to leave.