There is no significant changes vs There are no significant changes

Some examples from the web:

• there is no significant change in the strength and deformation capability of the superstructure.
• there is no significant change in mass distribution and centre of gravity positions.
• The moisture content of each soil is determined on three aliquots with heating at 105 oC until there is no significant change in weight (approximately 12 h).
• To be honest, there is no real, significant change.
• No significant changes in the pattern of consumption were confirmed.
• The proposal introduces no significant changes to the management and control of market expenditure.
• Phenotypic analysis showed no significant changes in emtricitabine susceptibility unless the M184V/ I mutation had developed.
• No significant changes in rufinamide concentration are observed following co-administration with lamotrigine, topiramate or benzodiazepines.
• But you agree there's no significant change.
• No significant changes are expected in this overall scenario in the foreseeable future.
• Her scans showed no significant changes.
• There have been no significant changes since the report was drawn up.
• With regard to the rights of the elderly, there are no significant changes to report compared to 2001.
• There will be no significant change in this ratio with EU enlargement and the accession of the 10 new Member States in 2004.
• No significant changes in requirements are introduced for Annexes IX and X.
• Age There were no significant changes observed in AUC of febuxostat or its metabolites following multiple oral doses of ADENURIC in elderly as compared to younger healthy subjects.
• Excepting inheritance, no significant change of ownership had taken place since the turn of the century.
• In that regard, the applicant submits that the reallocation made would cause no significant change to the programme.
• Renal impairment (mild, moderate and severe) resulted in no significant change in the pharmacokinetics of nevirapine.
• In the past five years there have been no significant changes in the budget implementation of the GSC (see Graph 1).

Some examples from the web:

• With regard to the rights of the elderly, there are no significant changes to report compared to 2001.
• The markets are relatively stable on the demand and the supply side, and there are no significant technological changes.
• No significant changes in the pattern of consumption were confirmed.
• The proposal introduces no significant changes to the management and control of market expenditure.
• Phenotypic analysis showed no significant changes in emtricitabine susceptibility unless the M184V/ I mutation had developed.
• No significant changes in rufinamide concentration are observed following co-administration with lamotrigine, topiramate or benzodiazepines.
• But you agree there's no significant change.
• No significant changes are expected in this overall scenario in the foreseeable future.
• Her scans showed no significant changes.
• There have been no significant changes since the report was drawn up.
• There are indications that Germany will exceed 3% deficit in terms of GDP.In France, the deficits in question are dangerously close to 3% and no significant change is expected next year.
• There are, however, some significant changes beneath these headline figures.
• But there are also benefits and significant changes underway on left-leaning policies.
• There will be no significant change in this ratio with EU enlargement and the accession of the 10 new Member States in 2004.
• No significant changes in requirements are introduced for Annexes IX and X.
• Age There were no significant changes observed in AUC of febuxostat or its metabolites following multiple oral doses of ADENURIC in elderly as compared to younger healthy subjects.
• Excepting inheritance, no significant change of ownership had taken place since the turn of the century.
• In that regard, the applicant submits that the reallocation made would cause no significant change to the programme.
• Renal impairment (mild, moderate and severe) resulted in no significant change in the pharmacokinetics of nevirapine.
• In the past five years there have been no significant changes in the budget implementation of the GSC (see Graph 1).