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lyophilized vs freeze-dried

Both 'lyophilized' and 'freeze-dried' are correct terms used in the context of removing water from a substance by freezing it and then sublimating the frozen water under vacuum. They are interchangeable and commonly used in scientific and pharmaceutical fields.

Last updated: March 26, 2024 • 1060 views

The term 'lyophilized' is correct and commonly used in scientific and pharmaceutical contexts to describe the process of freeze-drying.

"lyophilized"

It refers to the process of removing water from a substance by freezing it and then sublimating the frozen water under vacuum.

Examples:

  • The vaccine is lyophilized to increase its stability for storage and transportation.
  • The lyophilized powder can be reconstituted with water before use.
  • IVEMEND is a lyophilized prodrug of aprepitant containing polysorbate 80 (PS80) for intravenous administration.
  • Inject all the solvent in the syringe into the vial of lyophilized vaccine and gently agitate to mix thoroughly.
  • The inorganic, lyophilized form of arsenic trioxide, when placed into solution, immediately forms the hydrolysis product arsenious acid (AsIII).
  • In three comparative controlled trials, the immune response elicited by Rotarix liquid formulation was comparable to the one elicited by Rotarix lyophilized formulation.
  • Advate is to be administered intravenously after reconstitution of the lyophilized product with the provided sterilised water for injections.
  • Reconstitution instructions To reconstitute the vaccine, inject all the solvent in the syringe into the vial of lyophilized vaccine and gently agitate to mix thoroughly.
  • Powder for concentrate for solution for infusion White to off-white lyophilized cake or powder
  • The EEC standard for bovine PPD has a potency of 50000 Community tuberculin units (CTU) per mg of PPD and is dispensed lyophilized in ampoules containing 1,8 mg of PPD, i.e. 0,00002 mg PPD has a potency equal to one Community tuberculin unit.
  • Appearance of the powder: white lyophilized pellet Appearance of the solvent: clear colourless solution
  • Lyophilized vials containing a reconstituted dose of 25 mg/ ml are available from which doses less than 25 mg can be administered.
  • Add the water for injections by slow drop-wise addition down the side of the vial and not directly onto the lyophilized cake.
  • lyophilized PPD tuberculins: eight years;
  • 8 wise addition of the water for injection down the inside of the vial and not directly onto the lyophilized cake.
  • This is done by slow drop- wise addition of the water for injection down the inside of the vial and not directly onto the lyophilized cake.
  • In addition to its content in international agglutinating units, 1 ml of this lyophilized bovine serum must contain 1000 sensitizing units which fix the complement.
  • ADVATE is to be administered intravenously after reconstitution of the lyophilized product with the provided sterilised water for injections.
  • Powder for concentrate for solution for infusion White to off-white lyophilized cake or powder

Alternatives:

  • freeze-dried
  • cryodesiccated
  • sublimated
  • dried under vacuum

The term 'freeze-dried' is correct and commonly used in scientific and pharmaceutical contexts to describe the process of lyophilization.

"freeze-dried"

It refers to the process of removing water from a substance by freezing it and then sublimating the frozen water under vacuum.

Examples:

  • The freeze-dried coffee retains its flavor and aroma.
  • The freeze-dried fruit is lightweight and easy to transport.
  • Reteplase is supplied as a freeze-dried substance in vials.
  • Aseptically reconstitute the freeze-dried vaccine with 0.3 ml of the sterile solvent provided.
  • Preparation of NeoRecormon Multidose solution (1) Take the vial with the freeze-dried substance out of the package.
  • The freeze-dried fraction must be reconstituted with 1 ml of the specific diluent to obtain a solution containing 5 MU of recombinant interferon.
  • the nature and quantity of the reconstituting liquid for the freeze-dried preparation.
  • Except where the context otherwise requires, throughout the nomenclature any reference to 'dried' products also covers products which have been dehydrated, evaporated or freeze-dried.
  • Aseptically reconstitute the freeze-dried vaccine with 0.3 ml of the sterile solvent provided.
  • Piñatas and tacos and freeze-dried ice cream.
  • Every foodstuff on board is either frozen, freeze-dried, canned or packaged.
  • The final product shall be freeze-dried.
  • Master stocks of the organism are stored as freeze-dried ampoules.
  • Monoclonal antibody: 3-17-A3 (supplied as hybridoma tissue-culture supernatant) directed against the group-specific polypeptide VP7, stored at -20 ºC or freeze-dried and diluted 1/100 with blocking buffer before use.
  • We haven't asked ourselves, why freeze-dried?
  • Every day Stephen eats the same meal - a freeze-dried vegetarian lasagne, hermetically sealed for maximum life expectancy.
  • This also applies to human blood, regardless of its state (liquid, solid, frozen, freeze-dried etc.).
  • During preparation no antiseptic or bacteriostatic substance shall be added. The final product shall be freeze-dried.
  • When dissolving more than one sphere, it should be checked visually whether all freeze-dried material has dissolved completely before the solution is transferred to the next ampoule to be reconstituted.
  • What INVANZ looks like and contents of the pack INVANZ is a sterile, white to off-white, freeze-dried powder.
  • Since the stability of IBV in suspension may be low due to sensitivity to high temperatures and impurities, water used for dissolving the freeze-dried vaccine should be cool and of good quality.
  • The freeze-dried fraction must be reconstituted with 1 ml of the specific diluent to obtain, depending on the presentation, a suspension containing 5 MU or 10 MU of recombinant interferon.

Alternatives:

  • lyophilized
  • cryodesiccated
  • sublimated
  • dried under vacuum

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