however unfortunately vs however unfortunately it

Some examples from the web:

• However, unfortunately this does not seem to be the [...] case, and I ... father and his recovery, however, unfortunately, his father passed away [...] as a result of ...
• Sentence adverbs (words like however, unfortunately, surprisingly that modify a whole sentence) often require one or two commas, depending on their position ...
• Sep 26, 2012 ... The Economist.com Style Guide favors "but" over "however." Unfortunately, I see a lot of unnecessary wordiness in the posts as a result.
• However, unfortunately other people knew this before we did. A very long time ago over 3,000 years ago Egyptian, Babylonian and Greek Mathematicians ...

Some examples from the web:

• As far as we know there is no memory leakage (ALLOCATE without DEALLOCATE), however unfortunately it is impossible to be entirely sure that no leakage ...
• However, unfortunately it is not that simple; sudden death is not the same as ICD- preventable death. While ICD prophylaxis always reduces arrhythmic death, ...
• May 16, 2014 ... I had the ablation at aged 17, however, unfortunately it did not work and I had an episode 6 weeks later - frustrating! However, it has somewhat ...
• Dec 21, 2015 ... However, unfortunately, it seems the result of the non_negative_derivative can't be divided by a constant (as my counters are in 0.01 m3).