DNA damage vs DNA injury

Both 'DNA damage' and 'DNA injury' are correct phrases, but 'DNA damage' is more commonly used in scientific contexts. 'DNA injury' is less common but can still be used to refer to harm or damage to DNA.

Last updated: March 29, 2024 • 421 views

DNA damage

This phrase is correct and commonly used in scientific contexts to refer to harm or changes to DNA.

'DNA damage' is used to describe harm or changes to DNA caused by various factors such as radiation, chemicals, or errors in replication.

Examples:

Exposure to UV radiation can cause DNA damage.
Repair mechanisms can fix DNA damage caused by mutagens.

Show examples from the web [+]

The results of research showing that the herbicide can not only cause deformities, but also hormone imbalances, DNA damage and cancer, were apparently ignored.
During the ordovician extinction, Earth could have been blasted with enough deadly radiation from the galactic bow shock to unleash genetic mutations and DNA damage that wiped out over half of all species.
The end point measured is indicative of DNA damage and subsequent repair in liver cells.
In in vivo studies in rats, atazanavir did not induce micronuclei in bone marrow, DNA damage in duodenum (comet assay), or unscheduled DNA repair in liver at plasma and tissue concentrations exceeding those that were clastogenic in vitro.
If negative in 6.6.4 but positive in-vitro tests then undertake a second in-vivo study to examine whether mutagenicity or evidence of DNA damage can be demonstrated in tissue other than bone marrow
Mirtazapine was not genotoxic in a series of tests for gene mutation and chromosomal and DNA damage.
It is thus an appropriate site to measure DNA damage in vivo.
assaying other kinds of DNA damage.
The liver is usually the major site of metabolism of absorbed compounds. It is thus an appropriate site to measure DNA damage in vivo.
In addition, it is possible that a mutagen reacts with DNA but the DNA damage is not repaired via an excision repair process.
The cytotoxic effects of azacitidine may result from multiple mechanisms, including inhibition of DNA, RNA and protein synthesis, incorporation into RNA and DNA, and activation of DNA damage pathways.
assay for DNA damage, e.g. by alkaline elution, in somatic cells.
Saquinavir does not induce chromosomal damage in vivo in the mouse micronucleus assay or in vitro in human peripheral blood lymphocytes and does not induce primary DNA damage in vitro in the unscheduled DNA synthesis test.
A positive result from the UDS test with mammalian liver cells in vivo indicates that a test substance induces DNA damage in mammalian liver cells in vivo that can be repaired by unscheduled DNA synthesis in vitro.
DNA DAMAGE AND REPAIR - UNSCHEDULED DNA SYNTHESIS - MAMMALIAN CELLS IN VITRO
The Kalrsruhe study indicated DNA damage in rat and human cells, and this could potentially lead to carcinogenic or mutagenic effects in those eating these foods.
assay for DNA damage, e.g. by alkaline elution, in somatic cells.
however, there is not a perfect correlation between this test and carcinogenicity. Correlation is dependent on chemical class and there is increasing evidence that there are carcinogens that are not detected by this test because they appear to act through mechanisms other than direct DNA damage.
The end-point measured is indicative of DNA damage and subsequent repair in liver cells.

Alternatives:

genetic damage
nucleic acid damage
DNA degradation
DNA modification
DNA mutation

DNA injury

This phrase is correct but less commonly used than 'DNA damage'. It can still be used to refer to harm or damage to DNA.

'DNA injury' can be used to describe harm or damage to DNA, similar to 'DNA damage', but it is less frequently used in scientific literature.