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apoE-KO mice (B6.129P2-Apoetm1Unc/J) vs apoE-KO (B6.129P2-Apoetm1Unc/J) mice

Both phrases are correct and commonly used. The difference lies in the order of the words 'apoe-ko' and 'mice'. The choice between the two depends on the emphasis the speaker wants to place. If the focus is on the type of mice, 'apoe-ko mice' is preferred. If the emphasis is on the genetic modification, 'apoe-ko' is placed before 'mice'.

Last updated: March 26, 2024 • 1009 views

apoE-KO mice (B6.129P2-Apoetm1Unc/J)

This phrase is correct and commonly used in scientific contexts to refer to mice with a specific genetic modification.

This phrase is used to describe mice that are genetically modified to lack the apolipoprotein E gene. The term 'apoe-ko' specifies the genetic modification, and 'mice' indicates the animal model.
  • After 2 years administration of darunavir at exposures at or below the human exposure, kidney changes were observed in mice (nephrosis) and rats (chronic progressive nephropathy).
  • Fertility In fertility studies gemcitabine caused hypospermatogenesis in male mice (see section 5.3).
  • Fertility In fertility studies gemcitabine caused hypospermatogenesis in male mice (see section 5.3).
  • Cladribine is teratogenic in mice (at doses of 1.5 - 3.0 mg/ kg/ day, given on gestation days 6 - 15).
  • It is necessary to establish the MICE (Medicines Investigation for the Children of Europe).
  • Air Malta will apply industry standard practices to revenue management, pricing and increasing focus on MICE (Meetings, incentives, conferencing, exhibitions), corporate travel and tour operator relationships.
  • Systemic exposures of atazanavir in mice (males), rats, and dogs at doses associated with hepatic changes were at least equal to that observed in humans given 400 mg once daily.
  • Systemic exposures of atazanavir in mice (males), rats, and dogs at doses associated with hepatic changes were at least equal to that observed in humans given 400 mg once daily.
  • Another study in juvenile mice (treated on postnatal days 4 to 21) has demonstrated that inhibition of the serotonin transporter had long lasting effects on the behaviour of the mice.
  • Another study in juvenile mice (treated on postnatal days 4 to 21) has demonstrated that inhibition of the serotonin transporter had long lasting effects on the behaviour of the mice.
  • In finishing, Mr President, I would like to voice my support for rapporteur Françoise Grossetête's idea to set up the MICE (Medicines Investigation for the Children of Europe) agency.
  • The challenge procedure involves the administration of tetanus toxin to guinea pigs (method A) or mice (method B), resulting in paralysis and death.
  • Hey. Such a sight in your life, those three blind mice (Clicking continues)
  • Carcinogenicity Systemic carcinogenicity studies in mice (18 months) and rats (24 months) revealed no carcinogenic potential of tacrolimus.
  • This Community programme shall be called MICE (Medicines Investigation for the Children of Europe).
  • Taking into consideration that a vast historical database exists for mice and thus to broaden the scope of the Uterotrophic Bioassay test method in rodents to the use of mice as test species, a limited follow-up validation study was carried out in mice (16).
  • Dose related toxicities on male reproductive organs have been observed in mice, rats and dogs, and toxicities on female reproductive organs have been observed in mice (see section 5.3).
  • Stavudine was carcinogenic in mice (liver tumours) and rats (liver tumours: cholangiocellular, hepatocellular, mixed hepatocholangiocellular, and/ or vascular; and urinary bladder carcinomas) at very high exposure levels.
  • Systemic carcinogenicity studies in mice (18 months) and rats (24 months) revealed no carcinogenic potential of tacrolimus.
  • The plasma exposures (AUC values) in rats (maximum dose 1000 mg/kg/day) and in mice (maximum dose 2500 mg/kg/day) were lower than the expected plasma exposures obtained in humans at the recommended clinical dose of ritonavir boosted Invirase.

Alternatives:

  • mice with apoe-ko genotype (b6.129p2-apoetm1unc/j)

apoE-KO (B6.129P2-Apoetm1Unc/J) mice

This phrase is correct and commonly used in scientific contexts to refer to mice with a specific genetic modification.

This phrase is used to describe mice that are genetically modified to lack the apolipoprotein E gene. The term 'apoe-ko' specifies the genetic modification, and 'mice' indicates the animal model.
  • The biological efficacy of erythropoietin has been demonstrated in various animal models in vivo (normal and anaemic rats, polycythaemic mice).
  • Conventional carcinogenicity rodent studies with low exposures compared to human exposure under therapeutic conditions (factor 0.1 in rats and 1 in mice) did not reveal tumorigenicity of ribavirin.
  • The Commission intends to examine the possibility of setting up a paediatric study programme: Medicines Investigation for the Children of Europe (MICE), taking into consideration existing Community Programmes.
  • 2.6 The Commission intends to examine the possibility of setting up a paediatric study programme: Medicines Investigation for the Children of Europe (MICE), taking into consideration existing Community Programmes.
  • The biological efficacy of epoetin alfa has been demonstrated in various animal models in vivo (normal and anaemic rats, polycythaemic mice).
  • The challenge procedure involves the administration of tetanus toxin to guinea pigs (method A) or mice (method B), resulting in paralysis and death.
  • There was an increased incidence of tumours (hepatocellular adenomas) in mice exposed for 2 years to high doses (> 75 times human exposure), but this was considered secondary to prasugrel-induced enzyme-induction.
  • Overnight fasting of the animals (with the exception of mice) prior to blood sampling is recommended [5].
  • IgE measurements (e.g. in mice), or
  • It is necessary to establish a Community programme for research into medicinal products for children (Medicines Investigation for the Children of Europe - MICE).
  • Paclitaxel has been shown to be clastogenic in vitro (chromosome aberrations in human lymphocytes) and in vivo (micronucleus test in mice).
  • At the highest tested doses, the systemic exposures (based on AUC) to darunavir were between 0.4- and 0.7-fold (mice) and 0.7- and 1-fold (rats), relative to those observed in humans at the recommended therapeutic doses.
  • The median lethal doses were approximately 210 mg/ kg (mice) and 175 mg/ kg (rats).
  • Paclitaxel has been shown to be genotoxic in vivo (micronucleus test in mice), but it did not induce mutagenicity in the Ames test or the Chinese hamster ovary/ hypoxanthine-guanine phosphoribosyl transferase (CHO/ HGPRT) gene mutation assay.
  • Lastly, in its explanatory memorandum the Commission mentions the possibility of setting up the Medicines Investigation for the Children of Europe (MICE) programme, but makes no reference to it in the regulation itself.
  • To this end, the implementation of the Medicines Investigation for the Children of Europe (MICE) Programme will be promoted
  • The no- effect dose in rats was 25 mg/kg (5-fold human exposure based on AUC) and in mice 750 mg/kg (142- fold human exposure).
  • Reductions in testicular weights and/ or histological lesions (e. g., tubular atrophy and tubular giant cells) were observed in mice, rats, and monkeys.
  • The plasma exposures (AUC values) in rats (maximum dose 1000 mg/kg/day) and in mice (maximum dose 2500 mg/kg/day) were lower than the expected plasma exposures obtained in humans at the recommended clinical dose of ritonavir boosted Invirase.
  • On what is the Commission basing its elimination of biological testing (tests on mice) as the reference method for testing to detect marine biotoxins?

Alternatives:

  • mice with apoe-ko genotype (b6.129p2-apoetm1unc/j)

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