2-fold vs 2 fold

Both "2-fold" and "2 fold" are correct, but they are used in different contexts. "2-fold" is used as an adjective to describe something that has been folded twice, while "2 fold" is used as a noun to indicate a doubling or increase by two.

Last updated: March 27, 2024

2-fold

This is correct and commonly used in English.

Use "2-fold" when you want to describe something that has been folded twice, such as a piece of paper or a garment.

Examples:

The fabric was creased in a 2-fold pattern.
The brochure was designed with a 2-fold layout.

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An approximately 2-fold increase in steady-state AUC is estimated in patients with severe hepatic impairment.
Absorption continues for over one month, and monthly administration results in an approximate 2-fold accumulation.
Cmax is nearly 2-fold greater than in adults receiving a 10 mg tablet.
However, the plasma concentration of a metabolite of midazolam, 1'-hydroxymidazolam, was increased approximately 2-fold with multiple doses of laropiprant.
Plasma concentrations of bosentan metabolites increased about 2-fold in these patients as compared to subjects with normal renal function.
paediatric and adult patients in the area under the curve from time 0 to infinity (AUC[0-∞]) was observed; however, this difference was less than the 2-fold range in AUC(0- ∞) observed for the ro
The plasma clearance (ml/ min/ kg) of ertapenem in patients 3 months to 12 years of age is approximately 2-fold higher as compared to that in adults.
Co-administration of 200 mg bid ketoconazole, a strong inhibitor of CYP3A4, caused an approximate 2-fold increase in cinacalcet levels.
Renal impairment: end stage renal disease (ESRD) patients receiving dialysis had a 2-fold higher duloxetine Cmax and AUC values compared to healthy subjects.
Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology or repeated dose toxicity at 2-fold the maximum human exposure to parecoxib.
Results from an vivo interaction study reported in literature show that glimepiride AUC is increased approximately 2-fold by fluconazole, one of the most potent CYP2C9 inhibitors.
Differences in plasma concentrations were observed, with Cmax and AUC being approximately 3- and 2-fold higher, respectively, in females compared to males.
The increase is approximately 1.5- to 2-fold, corresponding to a 1.5-fold elevation of plasma AGP, to which imatinib binds strongly.
However, when given concurrently with Kaletra a mean 5-fold and 2-fold increase in rosuvastatin Cmax and AUC, respectively, was observed.
Embryo-foetal development studies were conducted with doses between 0.2- and 2-fold (rats) and between 1- and 4-fold (rabbits) the proposed therapeutic maintenance dose of 100 mg/ day.
Maternal body weight gain and fetal body weights were reduced in rabbits given a dose approximately 2-fold the adult human dose.
Biliary hyperplasia was observed in cynomolgus monkeys given efavirenz for >= 1 year at a dose resulting in mean AUC values approximately 2-fold greater than those in humans given the recommended dose.
Administration of raltegravir following a high-fat meal increased AUC and Cmax by approximately 2-fold and increased C12 hr by 4.1-fold.
20-39 ml/ min.), the results showed a significant 2-fold increase of the exposure (AUC) and half-life (t1/ 2) as compared to subjects with normal renal function.
Severe renal impairment decreased the renal clearance of methylnaltrexone by 8- to 9-fold; however, this resulted in only a 2-fold increase in total methylnaltrexone exposure (AUC).

Alternatives:

double-fold
twofold
folded twice
folded in two
two times folded

2 fold

This is correct but used in a different context than "2-fold".

Use "2 fold" when you want to indicate a doubling or increase by two, such as in a financial context or when talking about a two-fold change.